Comprehensive genomic and epigenomic profiling with the Oxford Nanopore Hereditary Cancer Panel

Overview

The Oxford Nanopore Hereditary Cancer Panel (HCP) targets 258 predisposition genes using adaptive sampling of long nanopore reads, enabling comprehensive detection of single nucleotide variants, insertions/deletions, structural variants, pseudogenes, and repetitive regions, alongside low-pass whole-genome coverage to enable copy number variant detection in a flexible workflow. The panel also enables direct methylation profiling without additional sample preparation.

This application note highlights how the HCP provides a scalable, accessible, and cost-effective solution for comprehensive analysis of hereditary cancer genes, with the potential to advance precision oncology.

In this application note, you will:

• Learn the importance of comprehensive detection of variants, many of which are missed by short-read methods
• Discover how adaptive sampling has the potential to provide a transformative alternative to traditional targeted sequencing approaches
• View our benchmarking data generated using the HCP