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Webinar: rAAV genome sequencing uncovers transgene integrity and packaging impurities


Recombinant adeno-associated viruses (rAAVs) are considered a promising delivery system for gene therapy medicines. This webinar highlighted how nanopore sequencing was evaluated as a comprehensive and sensitive QC method for rAAVs, supporting internal research activities at AstraZeneca.

During this webinar, viewers learnt:

  • Raw material validation through whole plasmid sequencing

  • ITR-ITR sequencing of whole AAV genomes and truncation hotspot detection

  • Contamination detection in bioreactor batches through sequencing of residual DNA

Authors: Daniel Jachimowicz, Senior Bioscience Scientist and Bastian Schiffthaler, Senior Data Scientist from AstraZeneca BioPharmaceuticals R&D, Sweden.

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