Exploring the methylation dimension with native DNA sequencing
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Epigenetic features like CpG methylation have a profound influence on phenotype that is not fully captured in the underlying DNA sequence. Oxford Nanopore sequencing reads these modifications directly from native DNA without chemical or enzymatic conversion, enabling methylation sequencing alongside comprehensive variant calling and phasing — all from a single sequencing run.
Join this webinar to learn more about leveraging Oxford Nanopore gold standard methylation sequencing in your research. We’ll cover methylation accuracy benchmarks versus traditional methods and we’ll dive into the powerful features of the state-of-the-art methylation analysis tool ModKit.
You will learn:
How native DNA sequencing enables direct methylation detection without PCR, bisulfite conversion, or additional sample processing.
What the latest benchmarking data reveals about methylation detection accuracy across multiple methods, including short-read approaches.
Best practices for analysing base modification information with ModKit, including quality control and validation, exploratory data analysis, and biological interrogation.
Meet the speakers
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Art Rand, Research Scientist, Machine Learning, Oxford Nanopore TechnologiesArthur (Art) Rand joined the research team at Oxford Nanopore Technologies (ONT) in 2022. His interests span developing basecalling and base modification detection models to secondary analysis software. Arthur is the lead developer of the Modkit software package from ONT. When not at work, he can probably be found on his bike in the mountains of the central coast of California.
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Daniel Garalde, Director, Segment Marketing - Emerging Omics , Oxford Nanopore TechnologiesDaniel used nanopores to study single molecule DNA-protein complexes in the nanopore research group at University of California Santa Cruz where he completed a Ph.D in computer engineering. At Oxford Nanopore Daniel drove forward-looking research projects including development of nanopore cDNA and Direct RNA sequencing. Daniel currently works to bring novel Oxford Nanopore solutions including full-length single cell sequencing and ultra-rapid WGS to key markets.
