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Ailsa MacCalman

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Job title
Institution
University of Exeter, UK
Biography

Ailsa MacCalman received her PhD in Medical Studies from the University of Exeter in 2023. During her PhD with Professor Jon Mill, Ailsa investigated the genomics of human fetal pancreas development. She investigated the epigenetic and transcriptomic changes regulating pancreatic development and their implications in pancreatic disease. Following her PhD, Ailsa began her postdoctoral research with Dr. Nick Owens, who is supported by a Wellcome Career Development award, investigating the cis-regulatory code. She uses sequence changes in rare and common pancreatic diseases as a model to gain insight into genomic regulation.

Recent publications

Wakeling, M. N. et al. Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism. Nat Genet. 54(11):1615–1620 (2022).
DOI: 10.1038/s41588-02201204-x

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