RNA N6-adenine methylation dynamics impact Hyaloperonospora arabidopsidis resistance in Arabidopsis

Studying N⁶-adenine methylation (m⁶A) changes during the biotic stress response in Arabidopsis is challenging with immunoprecipitation techniques. To overcome these challenges, the authors used direct RNA nanopore sequencing to resolve exact m⁶A positions at single nucleotide resolution. The team discovered m⁶A changes during the defence response against the parasite, H. arabidopsidis, and concluded that m⁶A could be a promising target to investigate for improved crop resistance against pathogens.