Oxford Nanopore at ASHG 2022: One sequencing platform for all your biology

Next week at the American Society for Human Genetics meeting, Oxford Nanopore will provide updates to the genomics community on the latest sequencing developments and the newest sequencing technology, the PromethION 2 Solo.

Using Oxford Nanopore sequencing technology, it is now possible to resolve variants and epigenetic modifications across the entire genome, target large panels or single genes without PCR, and detect known and novel full-length transcripts — up to single-cell resolution. All your biology on one platform.

This meeting will also provide the opportunity to see Oxford Nanopore’s latest device, the PromethION 2 Solo (P2 Solo). The compact P2 Solo device brings the benefits of high-coverage, real-time nanopore sequencing to every lab. Offering the flexibility of two independent, high-output PromethION Flow Cells, each capable of delivering up to 290 Gb* of data, these devices enable low-cost, high-depth, high-accuracy DNA/RNA sequencing across multiple experiments and users.

Throughout this year’s ASHG conference there will be many opportunities to see the technology in action and to meet the team. Full details of this are outlined below.

CoLabs and seminars:

The sequencing platform for multiomics – where will Oxford Nanopore’s PromethION take you?

CoLab (Wednesday, October 26, 4:30 PM – 5:00 PM, Theater 2)

In this CoLab, Oxford Nanopore Technologies will share how you can amplify your biological discovery with one scalable sequencing platform – from small projects to population scale initiatives. Hear how nanopore sequencing enables high-accuracy variant detection, built-in methylation, long-read single-cell transcriptomics, and more. Attendees will also learn how researchers are turning to nanopore sequencing to answer the biological questions that are otherwise eluding them. What will you discover?

Presented by:

Brian Fritz, Senior Director, Product Management, Oxford Nanopore Technologies

James Brayer, Director, Field Product Management, Oxford Nanopore Technologies

Unravelling complex human genomes – one sequencing platform for all your biology

Industry Education/Lunch Seminar (Thursday, October 27, 12:30 PM – 1:30 PM, Theater 411)

Hear from scientists using Oxford Nanopore’s technology to interrogate the intricacies of the human genome, including previously inaccessible structural, methylated, and phased variants. Learn how highly-scalable nanopore sequencing is being used from targeted panels, to population-scale methylation sequencing in large-scale national cohort studies, to long-read single-cell transcriptomics. To conclude the session Rosemary Sinclair Dokos, SVP of Product and Programme Management at Oxford Nanopore Technologies, will share how the latest technological advancements in nanopore sequencing enable high-accuracy sequencing of genetic variation at all read lengths, all on one multiomics platform.

Presented by:

Danny E. Miller, Assistant Professor, University of Washington and Seattle Children's Hospital, Seattle, WA

Fritz Sedlazeck, Associate Professor, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Computer Science, Rice University, Houston, TX

Carolyn A. Morrison, Applications Scientist, 10x Genomics

Rosemary Sinclair Dokos, SVP, Product and Programme Management, Oxford Nanopore Technologies

It takes two – haplotype specific identification of genetic and epigenetic variation using nanopore sequencing

CoLab (Friday, October 28, 12:15 – 12:45 PM, Theater 3)

In this CoLab presentation, we will share how nanopore long-read sequencing can be used to accurately identify genetic and epigenetic variation using a single dataset and illustrate the importance of assigning variants to the correct haplotype through phasing. We will show how Oxford Nanopore’s adaptive sampling enables genome-wide characterisation of methylation patterns across samples of interest in a cost-effective way as well as how to use data from Oxford Nanopore’s chromosome conformation capture protocol (Pore-C) to achieve parent-of-origin inference without the need for trio-sequencing. Finally, we will show how nanopore sequencing can improve the understanding of tumour development by enabling haplotype-specific copy number variation and DNA methylation profiling in heterogeneous tumours.

Presented by:

Philipp Rescheneder: Director, Genomic Applications Bioinformatics, Oxford Nanopore Technologies

Visit us in Oxford Nanopore Technologies booth #1721 for live product demonstrations during exhibit hall hours. Follow us for updates @nanopore.

Demonstrations

The following demonstrations will take place at the Oxford Nanopore Technologies booth #1721:

	Time	Demonstration
Wednesday	12:30 PM PDT	Not just for long reads – sequencing short fragments with nanopore sequencing
	3:00 PM PDT	High throughput sequencing with Oxford Nanopore Technologies
Thursday	10:15 AM PDT	Built in methylation from nanopore sequencing
	3:30 PM PDT	Sequencing full-length single cell transcripts with nanopore sequencing
Friday	10:15 AM PDT	Sequencing for highly accurate genomic variation with Oxford Nanopore

Presentations and posters

A full list of all presentations and posters featuring Oxford Nanopore is available here.