Real-time genomics for rapid clinical pathogen identification and resistance prediction in bloodstream infections
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Why focus on gram-negative bacteria?
• Gram-negatives as WHO pathogens of concern due to their growing resistance rates
• Natural inhabitants of the GI-tract of humans and animals
- High exposure to antibiotics
- High potential for transmission
In particular, Klebsiella pneumoniae harbours an abundance of resistance and virulence genes
Why use real-time genomics for bloodstream infections?
• Genomic information to understand evolution and transmission
• Metagenomics to assess the entirety of microorganisms in the bloodstream
• Rapid identification of resistance and virulence patterns
• Reduction of turnover time
