Long reads vs short reads: identification and quantification of known and novel isoforms implicated in neuropsychiatric disorders
- Published on: May 28 2022
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Neuropsychiatric disorders are a spectrum of complex and highly debilitating conditions. Genetic risk plays an important part and many risk genes are being identified, but the underlying disease mechanisms are poorly understood. Genome-wide association studies (GWAS) have led to the discovery of disease-associated loci and the importance of non-coding and intergenic regions in disease risk. While traditional RNA Sequencing methods can be limited in their scope, RNA CaptureSeq provides enhanced resolution and improved sensitivity to identity novel and/or lowly expressed isoforms in the coding and non-coding region of the genome.
