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Cecilia Yeung with Olga Sala-Torra

Clinical applications for real-time sequencing in leukaemia

About Cecilia Yeung with Olga Sala-Torra

Dr. Cecilia Yeung is an Associate Member at the Fred Hutchinson Cancer Research Center where she serves as the medical director of the Molecular Oncology Laboratory. She is an Assistant Professor at the University of Washington, Department of Anatomic Pathology where she serves as the chair of the Clinical Competency Committee for the Molecular Genetics Pathology Fellowship, and the director for the Molecular Pathology Elective. She is the co-coordinator and speaker of the Molecular Pathology Lecture Series for residents and fellows. She is a member of the Board of Directors and the chair of the Teaching and Education Committee at the Association for Molecular Pathology.  Her clinical appointment at Seattle Cancer Care Alliance is where she focuses her pathology diagnostic skills in immunotherapy, transplant, and hematopathology. Her research interest focuses on developing novel molecular diagnostics for hematologic malignancies, and improving correlative data from clinical trials via implementation of better translational medicine diagnostic assays.

Dr. Olga Sala Torra is a staff scientist in the Radich laboratory at the Fred Hutchinson Cancer Research Center in Seattle, WA. Her main research interests are the application of gene expression and sequencing techniques to the detection of minimal residual disease in leukemias, and the development of low-cost diagnostic methods for hematologic malignancies that can be useful in low-income countries.

Recent publications

Sala Torra, O. et al. Next-Generation Sequencing in Adult B cell Acute Lymphoblastic Leukemia Patients. Biology of Blood and Marrow Transplantation 23, 691–696 (2017).

Torra, O. S., Beppu, L., Smith, J. L., Welden, L., Georgievski, J., Gupta, K. Radich, J. P. (2016, June 2). Paper or plastic? BCR-ABL1 quantitation and mutation detection from dried blood spots. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2015-12-689059

Abstract

Leukemias are characterized by a variety of distinct cytogenetic and molecular subgroups that impact response and survival. Many of these leukemias have specific translocations and mutations that confirm the suspected diagnosis, provide prognostic information, and guide therapy. A particular challenge in current molecular pathology practice is the high cost and long turnaround times for reporting of molecular profiles in these leukemias. Our research aims to use real-time sequencing for more efficient and improved molecular diagnostics workflows. Our work involves development of a real-time sequencing assay for detection of fusion genes and to sequence the FLT3 gene transcript to detect mutations in leukemias using the MinION platform.

Cecilia Yeung with Olga Sala-Torra

Cecilia Yeung with Olga Sala-Torra

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