Native telomere sequencing of individual chromosomes using 3’ end adapter ligation

Direct Oxford Nanopore adapter ligation to chromosome ends and base-calling models trained on telomeric repeat sequences enables precise telomere length and methylation analysis in human cells.

Download the poster to discover:

• The process of Oxford Nanopore adapter ligation to the telomere ends with the use of short telomere adapters
• More about a customised base-caller that identifies and maps enriched telomere sequences
• More about mapping individual telomere reads which enables comparative telomere length measurements
• How methylation patterns in native telomeres can be analysed using Remora

Download the PDF

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