Methylation and fragment analysis of native cfDNA reveals tissue of origin and nucleosome featuresPoster
Date: 5th December 2022
For the first time, methylation signatures have been identified in native cell-free DNA using Oxford Nanopore’s short-read sequencing mode, allowing genome-wide methylation patterns to be deduced.
Download the poster to discover:
- More about short cell-free fragments of DNA from lysed cells and their presence in the bloodstream
- More on, extraction and sequencing of cfDNA and their characteristic nucleosome footprints
- More about methylation calling of native cfDNA being used to predict tissue of origin
- More about nucleosome positioning and the identification of open and closed chromatin