Methylation and fragment analysis of native cfDNA reveals tissue of origin and nucleosome features

For the first time, methylation signatures have been identified in native cell-free DNA using Oxford Nanopore’s short-read sequencing mode, allowing genome-wide methylation patterns to be deduced.

Download the poster to discover:

• More about short cell-free fragments of DNA from lysed cells and their presence in the bloodstream
• More on, extraction and sequencing of cfDNA and their characteristic nucleosome footprints
• More about methylation calling of native cfDNA being used to predict tissue of origin
• More about nucleosome positioning and the identification of open and closed chromatin

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