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Large genome assembly Research Spotlight

Literature

Date: 22nd July 2019

Nanopore long sequencing reads simplify genome assembly and enable the comprehensive, genome-wide analysis of structural variants.

Schatz et al. sequenced 100 tomato genomes in 100 days, using the high-throughput PromethION™, to elucidate the role of structural variation in the development of key agricultural and phenotypic traits. This research provided a thorough characterisation of the structural variant (SV) landscape in a genetically diverse range of tomato genomes. Such insight offers the potential to enrich for desired agricultural traits using targeted genome editing.

Find out more in this Research Spotlight focused on large genome assembly.

Download the large genome assembly Spotlight

Read the publication

Applications Whole-genome sequencing with nanopore technology
Presentation Michael Schatz: 100 genomes in 100 days: The structural variant landscape in tomato genomes

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Cas9-Assisted Targeting of CHromosome segments (CATCH) for targeted nanopore sequencing and optical genome mapping Publication 1st Jan 2020
Buy the MinION Starter Pack Everything you need to explore the technology and the potential of real-time analysis for DNA or RNA. Buy MinION

Tags

Literature Assembly Structural variation Plant Whole genome gDNA PromethION Spotlight Population genomics
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