Comprehensive analysis of hereditary cancers with PCR-free targeted sequencing using adaptive sampling
PosterDate: 5th December 2022
Simple targeted sequencing of the human genome on a MinION Flow Cell allows SNP calling and phasing, methylation analysis, and genome-wide, low-pass copy number variant (CNV) analysis from a single nanopore sequencing dataset.
Download the poster to discover:
- How adaptive sampling can be used for targeted analysis of a gene panel, here encompassing 201 cancer-related genes and >15,000 promoter regions across the human genome
- How SNP calling and variant phasing can be performed on targeted nanopore sequence data, facilitating the study of compound heterozygosity
- How targeted sequencing with adaptive sampling is completely PCR-free, enabling you to directly capture methylation patterns
- How rejected, 'off-target' reads from adaptive sampling can be used to analysis CNVs
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