The sensor array chip
Oxford Nanopore has developed custom high- performance, low-cost Application-Specific Integrated Circuits (ASICs) for the MinION device, the PromethION and the GridION system. These ASICs apply biased potentials across each nanopore in the sensor array chip and measure the resulting ionic current flow.
These ASICs have been designed to measure current at very high sampling frequencies, tens of kHz per nanopore, while minimising measurement noise and maximising signal. Each ASIC contains a high-density array of low-noise amplifier circuitry, and can be scaled to measure from tens to thousands of channels, with further projects underway for larger chips. More than one ASIC may be included in a product if higher-throughput systems are required.