Products & Services
Applications

Applications

Nanopore sequencing offers advantages in all areas of research. Our offering includes DNA sequencing, as well as RNA and gene expression analysis and future technology for analysing proteins.

Learn about applications
View all Applications
Resources
News Explore
Contact

Applications Research areas

Infectious disease

Offering comprehensive, real-time insights into infectious disease samples — from pathogen identification and antimicrobial resistance (AMR) profiling to the assembly of high-quality genomes and variant identification — nanopore sequencing delivers immediate access to the critical genomic epidemiology data required for effective control of infectious disease outbreaks. Sequence in the lab or at sample source at a scale to suit your needs, with powerful portable and high-throughput nanopore sequencing devices. 

Evidence-based public health decision-making in the COVID-19 pandemic

Read the article
The combination of real-time whole genome sequencing with the data from the National Public Health response team has provided information that helped decide on the next steps in the decision-making Oude Munnink B.B. et al. Nature Medicine 26 (2020)

Oxford Nanopore sequencing

Traditional short-read technologies

Real-time data streaming
Rapid, real-time sequencing

  • Immediate access to actionable results, including pathogen identification, variant analysis, and antimicrobial resistance
  • Stop sequencing when sufficient data generated — wash and reuse flow cell
  • Comprehensive data analysis tools — including EPI2ME for real-time species identification and AMR profiling

Fixed run time with bulk data delivery

Increased time-to-result; less amenable to time-critical applications

Scalable — portable to high throughput
Portable, deployable sequencing

  • Sequence anywhere with portable, low-cost MinION devices — starting at just $1,000, including sequencing reagents
  • Scale up with modular GridION and PromethION — suitable for ultra-high-throughput sequencing of pathogen and complex metagenomic samples alongside other experiments, such as host genomics

Constrained to the lab

Considerable site infrastructure and set-up requirements combined with high platform costs can limit accessibility

Flexible and on-demand
On-demand sequencing

  • Scale your sequencing to your needs — run 1 to 1000s of samples on a single device
  • Sequence what you want, when you want — no sample batching required

Limited flexibility

Sample batching may be required for optimal efficiency, potentially delaying results until sufficient samples are acquired

Unrestricted read length (>4 Mb achieved)
Long-read sequencing

Read length typically 50–300 bp

Short reads do not typically span entire regions of interest, including repeats and structural variants, or full-length RNA transcripts, resulting in fragmented assemblies and ambiguous transcript isoform identification

Streamlined, automatable workflows
Fast sequencing workflows

Laborious workflows

Lengthy sample preparation with requirement for amplification — removing base modifications (e.g. methylation) and increasing the potential for sequencing bias

Briefing paper

Using real-time molecular epidemiology to manage infectious disease outbreaks

From Ebola, Zika, and COVID-19, to antimicrobial resistant bacterial and fungal infections, discover how portable, real-time nanopore sequencing is being utilised by researchers worldwide to support rapid identification and control of infectious disease outbreaks. Find out how real-time genomic epidemiology is supporting the tracking of novel pathogen variants to inform infection control and public health policy.

Get more infectious disease content, including getting started guides, workflows, white papers, and videos, in our Resource centre.

Case study

Local control of COVID-19 community and hospital outbreaks

As a new pandemic took hold across the UK, hospital admissions of patients with COVID-19 surged, including at the Cambridge University Hospitals. It was very important to understand where and how these infections were spreading to support the implementation of effective disease control measures. The recently established COVID-19 Genomics Consortium UK swung into action; a world-leading distributed network of hospitals, public health agencies, and academic partners, with a mission to provide rapid, high-throughput whole-genome sequencing of SARS-CoV-2 samples. The molecular epidemiology data generated was critical to implementing appropriate local and national public health policy. 

Studying the virus’s genome helps to highlight cryptic or hidden transmission. That’s the real power of it — you can detect outbreaks and act while they’re happening’

Estée Török, University of Cambridge, UK

From species identification to metagenome assembly and variant calling, get detailed information in our application pages.

Get started

Scalable sequencing of infectious disease samples

Fully scalable, real-time nanopore sequencing devices are available to suit all infectious disease sequencing requirements — from in-field pathogen surveillance and characterisation to high-volume analysis of outbreak samples and host genetics.

Compare products
Nanopore sequencing yield chart

Recommended for infectious disease sequencing

GridION

Running up to five independent MinION or Flongle Flow Cells with powerful, integrated compute, GridION provides the flexibility to run multiple experiments, on-demand — ideal for rapid and scalable analysis of pathogen samples and tracking novel variants.

PromethION 48

Combining up to 48 independently addressable, high-capacity flow cells with powerful, integrated compute, PromethION 48 delivers flexible, on-demand access to terabases of sequencing data.

View product

PromethION 24

Flexible, large-scale sequencing using up to 24 independent, high-capacity flow cells.

View product

MinION

Powerful, portable sequencing of pathogen samples from just $1,000, including sequencing reagents.

View product

MinION Mk1C

Fully integrated sequencing and analysis in a powerful handheld device — sequence at sample source.

View product

Flongle

Adapting MinION and GridION for the most cost-effective access to smaller, routine tests and analyses.

View product

VolTRAX

Portable, USB-powered sample extraction and library preparation device.

View product

Subscribe

Get in touch


Talk to us

If you have any questions about our products or services, chat directly with a member of our sales team.

Talk to us

Book a sales call

To book a call with one of our sales team, please click below.

Book a call
Open a chat to talk to our sales team
FAQs

FAQs

Search