Nanopore Digest: 9th May 2019
Thu 9th May 2019
Welcome to the Oxford Nanopore digest - a regular newsletter of updates from the nanopore community. You'll be able to find links to recent publications, presentations and other news. If you'd like to get the digest in your inbox please let us know.
Long read sequencing reveals a novel class of structural aberrations in cancers: identification and characterization of cancerous local amplifications
Up to a third of lung cancer patients remain undiagnosed with respect to their cancerous mutations. Sakamoto and colleagues used the high-throughput, long-read PromethION sequencing platform to identify point mutations and structural variants in lung cancer cell lines and patient samples. During their analysis they identified a class of complex structural aberrations consisting of copy number changes, inversions, and deletions, which they called Cancerous Local Copy number Lesions (CLCLs). These CLCLs could not be characterised by short-read sequencing, demonstrating the significant advantages provided by nanopore long reads in the thorough characterisation of genomic aberrations present in cancer.
London Calling 2019
Don't miss a thing with the Nanopore App! Download now to access all the information you need in one place, plan your conference using the app agenda and book technical clinics, available on the App store or Google Play. If you’re not registered to attend yet, you can join the wait list and we will contact you if a ticket becomes available. If you are already registered to attend then we hope you’ll consider joining us for a 5k run, walk or jog in Hyde Park on the 22nd May. Find out more.
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