Nanopore Digest: 19th September 2019

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Accurate detection of m⁶A RNA modifications in native RNA sequences

RNA modifications can profoundly impact RNA processing, stability and translation, and can modulate cancer risk, cell fate, and cellular processes. Oxford Nanopore is the only technology that can directly sequence native RNA and identify epigenetic modifications alongside nucleotide sequence. However, analysis tools for RNA modification detection are lacking. In this article, the authors present a novel algorithm, Epinano, to address this problem; they demonstrate that Epinano detects N⁶-methyladenosine (m⁶A) RNA modifications with a predictive accuracy of 90%.

You can watch Eva Maria Novoa's London Calling 2019 talk here.

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Publications

Complete characterization of the human immune cell transcriptome using accurate full-length cDNA sequencing

Rapid detection of genetic engineering, structural variation, and antimicrobial resistance markers in bacterial biothreat pathogens by nanopore sequencing

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Webinar Available to watch on demand: webinar from Ghamdan Al-Eryani on how 'Single-cell nanopore sequencing allows high throughput multi-omic analyses of cellular diversity in tumours'. Watch here

Submit your Nanopore Community Meeting abstract Join us to hear the latest research from the Nanopore Community, including plenaries, breakouts, posters, demos and more, on the 5th-6th December in New York. Register

CRISPR-Cas9 enrichment for nanopore sequencing Oxford Nanopore and Caribou Biosciences, Inc. have entered into a non-exclusive license agreement under which Caribou has granted Oxford Nanopore a worldwide, non-exclusive license under foundational CRISPR-Cas9 intellectual property controlled by Caribou for nanopore sequencing. Learn more