Nanopore Digest: 19th September 2019
Thu 19th September 2019
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Accurate detection of m6A RNA modifications in native RNA sequences
RNA modifications can profoundly impact RNA processing, stability and translation, and can modulate cancer risk, cell fate, and cellular processes. Oxford Nanopore is the only technology that can directly sequence native RNA and identify epigenetic modifications alongside nucleotide sequence. However, analysis tools for RNA modification detection are lacking. In this article, the authors present a novel algorithm, Epinano, to address this problem; they demonstrate that Epinano detects N6-methyladenosine (m6A) RNA modifications with a predictive accuracy of 90%.
You can watch Eva Maria Novoa's London Calling 2019 talk here.
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